S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

Base Information

Chemical Name:S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane
CAS No.:914955-90-1
Molecular Formula:C₃₂H₃₄F₂N₂O₅
Molecular Weight:564.629
Hs Code.:

Synonyms:S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

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Chemical Property of S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

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Technology Process of S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

There total 4 articles about S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 914955-85-4
S-(+)-2β-hydroxymethyl-3α-[bis(4-fluorophenyl)methoxy]tropane

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 914955-90-1
S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

Guidance literature:: 4-(4-nitrophenyl)butanoic acid; With thionyl chloride; for 3h; Heating;

S-(+)-2β-hydroxymethyl-3α-[bis(4-fluorophenyl)methoxy]tropane; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1021/jm060762q

Reference yield:

: 156774-35-5
O 620

: 914955-90-1
S-(+)-2β-{[4-(4'-nitrophenyl)butyryl]oxymethyl}-3α-[bis(4-fluorophenyl)methoxy]tropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

2.1: SOCl₂ / 3 h / Heating

2.2: 87 percent / triethylamine / CH₂Cl₂ / 3 h / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; In diethyl ether;
DOI:10.1021/jm060762q