2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol

Base Information

Chemical Name:2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol
CAS No.:1449696-91-6
Molecular Formula:C₁₇H₁₀F₆O₂
Molecular Weight:360.256
Hs Code.:

Synonyms:2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol

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Chemical Property of 2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol

Chemical Property:

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Technology Process of 2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol

There total 5 articles about 2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1449697-06-6
1-methoxy-2-((2-(methoxymethoxy)-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)benzene

: 1449696-91-6
2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 20h;
DOI:10.1021/jo400926n

Reference yield:

: C₁₄H₁₇F₃O₂Si

: 1449696-91-6
2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: triethylamine; trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide / 16 h / 20 - 70 °C / Sealed tube; Inert atmosphere

3: hydrogenchloride / methanol; dichloromethane / 20 h / 20 °C

With hydrogenchloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/jo400926n

Reference yield:

: 174265-24-8
4-(trifluoromethyl)phenyl methoxymethyl ether

: 1449696-91-6
2-((2-methoxy-5-(trifluoromethyl)phenyl)ethynyl)-4-(trifluoromethyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 22 h / -78 - 20 °C / Inert atmosphere

2.1: triethylamine; trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide / 18 h / 20 - 70 °C / Sealed tube; Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.1: triethylamine; trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide / 16 h / 20 - 70 °C / Sealed tube; Inert atmosphere

5.1: hydrogenchloride / methanol; dichloromethane / 20 h / 20 °C

With hydrogenchloride; copper(l) iodide; n-butyllithium; trans-bis(triphenylphosphine)palladium dichloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; 2.1: |Sonogashira Cross-Coupling / 4.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jo400926n