tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate
CAS No.:1616894-51-9
Molecular Formula:C₂₄H₃₀N₈O₅
Molecular Weight:510.553
Hs Code.:

Synonyms:tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate

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Chemical Property of tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate

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Technology Process of tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate

There total 8 articles about tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1234687-35-4
4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)benzoic acid

: 153086-78-3
tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

: 1616894-51-9
tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate

Guidance literature:: With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/ja502780z

Reference yield:

: 14080-23-0
2-cyanopyrimidine

: 1616894-51-9
tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate

2: sodium nitrite

3: thionyl chloride; N,N-dimethyl-formamide / 3 h / 90 °C

4: N-ethyl-N,N-diisopropylamine / chloroform / 0 - 20 °C

With thionyl chloride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium nitrite; In chloroform;
DOI:10.1039/c5cc03434e

Reference yield:

: 619-65-8,333406-09-0
4-cyanobenzoic Acid

: 1616894-51-9
tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate

2: sodium nitrite

3: thionyl chloride; N,N-dimethyl-formamide / 3 h / 90 °C

4: N-ethyl-N,N-diisopropylamine / chloroform / 0 - 20 °C

With thionyl chloride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium nitrite; In chloroform;
DOI:10.1039/c5cc03434e