3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Base Information

Chemical Name:3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid
CAS No.:380306-43-4
Molecular Formula:C₂₈H₄₄N₂O₇
Molecular Weight:520.667
Hs Code.:

Synonyms:3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Suppliers and Price of 3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

There total 8 articles about 3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyric acid 2-(1,1-dimethyl-3-oxo-propyl)-3,5-dimethyl-phenyl ester

: 380306-43-4
3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; In water; acetonitrile; at 0 - 20 ℃;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 380306-43-4
3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / 4-dimethylaminopyridine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

2: H₂ / Pd-C / ethanol / 2.5 h

3: 290 mg / CH₂Cl₂

4: glac. HOAc / tetrahydrofuran; H₂O / 1 h / 20 °C

5: pyridinium chlorochromate / CH₂Cl₂

6: 242 mg / NaH₂PO₄; NaClO₂ / H₂O; acetonitrile / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y

Reference yield:

: 134098-64-9
2‐{3‐[(O‐tert‐butyldimethylsilyl)hydroxy]‐1,1‐dimethylpropyl}‐3,5‐dimethylphenol

: 380306-43-4
3-[2-(N-Boc-L-valyl-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / 4-dimethylaminopyridine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

2: H₂ / Pd-C / ethanol / 2.5 h

3: 290 mg / CH₂Cl₂

4: glac. HOAc / tetrahydrofuran; H₂O / 1 h / 20 °C

5: pyridinium chlorochromate / CH₂Cl₂

6: 242 mg / NaH₂PO₄; NaClO₂ / H₂O; acetonitrile / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y