N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide
• CAS No.: 866354-43-0
• Molecular Formula: C₂₅H₂₅IN₂O₆S
• Molecular Weight: 608.454
• Mol file: 866354-43-0.mol

Synonyms:N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide

Chemical Property of N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide

There total 1 articles about N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-furaldehyde tosylimine (13707-47-6) + (S)-3-Cyclopropanecarbonyl-4-phenyl-oxazolidin-2-one → N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide (866354-43-0)

Guidance literature:

(S)-3-Cyclopropanecarbonyl-4-phenyl-oxazolidin-2-one; With diethylaluminum iodide; In dichloromethane; toluene; at 0 ℃; for 0.5h;

2-furaldehyde tosylimine; In dichloromethane; toluene; at 0 ℃; for 9h;

DOI:10.1021/jo0509051

Reference yield: 95.0%

N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide (866354-43-0) → (S)-3-[(2S,3R)-2-Furan-2-yl-1-(toluene-4-sulfonyl)-pyrrolidine-3-carbonyl]-4-phenyl-oxazolidin-2-one (866354-52-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo0509051

Reference yield:

N-[(1S,2R)-1-Furan-2-yl-4-iodo-2-((S)-2-oxo-4-phenyl-oxazolidine-3-carbonyl)-butyl]-4-methyl-benzenesulfonamide (866354-43-0) → (2S,3R)-2-Furan-2-yl-1-(toluene-4-sulfonyl)-pyrrolidine-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / triethylamine / CH₂Cl₂ / 2 h / 20 °C

2: 84 percent / lithium hydroxide; hydrogen peroxide / tetrahydrofuran; H₂O / 0 - 20 °C

With lithium hydroxide; dihydrogen peroxide; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jo0509051

upstream raw materials:

2-furaldehyde tosylimine

Downstream raw materials:

(S)-3-[(2S,3R)-2-Furan-2-yl-1-(toluene-4-sulfonyl)-pyrrolidine-3-carbonyl]-4-phenyl-oxazolidin-2-one