ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

Base Information

Chemical Name:ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate
CAS No.:1356633-34-5
Molecular Formula:C₂₈H₃₃FN₄O₅
Molecular Weight:524.592
Hs Code.:

Synonyms:ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

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Chemical Property of ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

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Technology Process of ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

There total 3 articles about ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356633-32-3
ethyl 3-chloro-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

: 92136-39-5
N-tert-Butoxycarbonyl-1-amino-3-propyne

: 1356633-34-5
ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 14h;

Reference yield:

: 1198475-22-7
5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid

: 1356633-34-5
ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

2: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 14 h / 90 °C

With copper(l) iodide; triethylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield:

: 70931-28-1
1-(4-fluorophenylmethyl)piperazine

: 1356633-34-5
ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

2: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 14 h / 90 °C

With copper(l) iodide; triethylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;