5-Chloro-6-(ethoxycarbonyl)nicotinic acid

Base Information

• Chemical Name: 5-Chloro-6-(ethoxycarbonyl)nicotinic acid
• CAS No.: 1198475-22-7
• Molecular Formula: C₉H₈ClNO₄
• Molecular Weight: 229.62
• Hs Code.: 2933399990
• Mol file: 1198475-22-7.mol

Synonyms:5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid

Chemical Property of 5-Chloro-6-(ethoxycarbonyl)nicotinic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

5-Chloro-6-(ethoxycarbonyl)nicotinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Chloro-6-(ethoxycarbonyl)nicotinic acid

There total 2 articles about 5-Chloro-6-(ethoxycarbonyl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 5,6-dichloronicotinic acid (41667-95-2) → 5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid (1198475-22-7)

Guidance literature:

With bis(triphenylphosphine)palladium(II) dichloride; triethylamine; 1,4-di(diphenylphosphino)-butane; at 135 ℃; for 4h; under 30003 Torr; Autoclave;

Reference yield: 76.0%

5,6-dichloronicotinic acid (41667-95-2) → 5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid (1198475-22-7)

Guidance literature:

With hydrogenchloride;

Reference yield: 75.0%

5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid (1198475-22-7) + 1-(4-fluorophenylmethyl)piperazine (70931-28-1) → ethyl 3-chloro-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate (1356633-32-3)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

upstream raw materials:

5,6-dichloronicotinic acid

ethanol

carbon monoxide

Downstream raw materials:

ethyl 3-chloro-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

ethyl 3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinate

3-(3-(tert-butoxycarbonylamino)prop-1-ynyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)picolinic acid

tert-butyl 3-(2-(1-(4-cyanobenzyl)piperidin-4-yl-carbamoyl)-5-(4-(4-fluorobenzyl)piperazine-1-carbonyl)pyridin-3-yl)prop-2-ynyl-carbamate

Refernces

• 1、 -. "OXIME GROUP-CONTAINING CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND OR THE SALT, AND METHOD FOR USING THE INSECTICIDE". Paragraph 0183-0185. . Retrieved 2020/03/28.
• 2、 -. "BENZOXAZOLE COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE". Paragraph 0139; 0140; 0141; 0142. . Retrieved 2019/02/24.