S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester

Base Information

• Chemical Name: S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester
• CAS No.: 856258-53-2
• Molecular Formula: C₂₇H₃₇NO₅
• Molecular Weight: 455.594

Synonyms:S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester

Chemical Property of S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester

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Technology Process of S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester

There total 5 articles about S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester (405271-21-8) → S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester (856258-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 100 percent / H₂ / Pd/C / ethanol / 27 °C / 2585.74 Torr

2.1: Na / tetrahydrofuran / 6 h / 50 °C

2.2: EDC / tetrahydrofuran / 25 °C

With hydrogen; sodium; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jo050268e

Reference yield:

(2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid (251454-49-6) → S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester (856258-53-2)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂SO₄ / 45 °C

2: H₂ / Pd/C / ethanol

3: TMSONa / tetrahydrofuran / 22 h / 34 °C

4: HOBt; EDCI / toluene / 2.25 h / 20 - 30 °C

With sulfuric acid; hydrogen; sodium trimethylsilanolate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene;

DOI:10.1021/ol050367e

Reference yield:

S-2-ethoxy-3-[4-(R-1-carboxyethoxy)phenyl]propionic acid isopropyl ester (853302-27-9) + 4-ethylphenylethylamine (64353-29-3) → S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester (856258-53-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In toluene; at 20 - 30 ℃; for 2.25h;

DOI:10.1021/ol050367e

upstream raw materials:

(S)-2-chloropropanoic acid

4-ethylphenylethylamine

(S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid isopropyl ester

S-2-ethoxy-3-[4-(R-1-carboxyethoxy)phenyl]propionic acid isopropyl ester

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