2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester

Base Information

• Chemical Name: 2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester
• CAS No.: 405271-21-8
• Molecular Formula: C₂₁H₂₆O₄
• Molecular Weight: 342.435
• Mol file: 405271-21-8.mol

Synonyms:2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester

Chemical Property of 2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester

There total 2 articles about 2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(4-benzyloxyphenyl)-2-hydroxypropionic acid isopropyl ester (481072-42-8) + ethyl iodide (75-03-6) + sodium tert-pentoxide (3561-85-1) → (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid (251454-49-6) + ethyl (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate (251454-50-9) + 2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester (405271-21-8) + (S)-3-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid 2,2-dimethyl-propyl ester

Guidance literature:

In N,N-dimethyl-formamide; toluene; at -30 ℃; for 2.5h;

DOI:10.1021/jo050268e

Reference yield:

(2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid (251454-49-6) + isopropyl alcohol (67-63-0,8013-70-5) → 2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester (405271-21-8)

Guidance literature:

With sulfuric acid; at 45 ℃;

DOI:10.1021/ol050367e

Reference yield: 100.0%

2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester (405271-21-8) → (S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid isopropyl ester (325793-71-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 27 ℃; under 2585.74 Torr;

DOI:10.1021/jo050268e

upstream raw materials:

3-(4-benzyloxyphenyl)-2-hydroxypropionic acid isopropyl ester

ethyl iodide

sodium tert-pentoxide

(2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid

Downstream raw materials:

(S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid isopropyl ester

S-2-ethoxy-3-[4-(R-1-carboxyethoxy)phenyl]propionic acid isopropyl ester

S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester