Technology Process of 2-benzyloxy-6-quinolinecarboxaldehyde
There total 3 articles about 2-benzyloxy-6-quinolinecarboxaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(benzyloxy)-6-bromoquinoline;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
N,N-dimethyl-formamide;
at -78 - 20 ℃;
Further stages.;
DOI:10.1021/ol006366y
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 79 percent / silver carbonate / CHCl3 / 48 h
2.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 42 percent / -78 - 20 °C
With
n-butyllithium; silver carbonate;
In
tetrahydrofuran; hexane; chloroform;
1.1: Substitution / 2.1: Metallation / 2.2: Formylation;
DOI:10.1021/ol006366y
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 79 percent / silver carbonate / CHCl3 / 48 h
2.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 42 percent / -78 - 20 °C
With
n-butyllithium; silver carbonate;
In
tetrahydrofuran; hexane; chloroform;
1.1: Substitution / 2.1: Metallation / 2.2: Formylation;
DOI:10.1021/ol006366y
