methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate

Base Information

Chemical Name:methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate
CAS No.:1403257-50-0
Molecular Formula:C₁₅H₂₀BrNO₃
Molecular Weight:342.233
Hs Code.:

Synonyms:methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate

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Chemical Property of methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate

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Technology Process of methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate

There total 6 articles about methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1403257-49-7
2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester

: 74-88-4
methyl iodide

: 1403257-50-0
methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate

Guidance literature:: With caesium carbonate; In acetonitrile; at 80 ℃; for 20h;

Reference yield: 52.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1403257-49-7
2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester

: 1403257-50-0
methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate

Guidance literature:: formaldehyd; 2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester; With acetic acid; In 1,2-dichloro-ethane; for 0.0833333h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 34h;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; pH=7;

Reference yield:

: 1000342-11-9
2-methyl-3-amino-5-bromobenzoic acid methyl ester

: 1403257-50-0
methyl 5-bromo-2-methyl-3-(methyl(tetrahydro-2H-pyran-4-yl)amino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 1,1-dichloroethane / 0.25 h / 20 °C

1.2: 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 20 h / 80 °C

With caesium carbonate; acetic acid; In 1,1-dichloroethane; acetonitrile;