(S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate

Base Information

Chemical Name:(S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate
CAS No.:1369487-45-5
Molecular Formula:C₁₆H₁₄FNO₂S
Molecular Weight:303.357
Hs Code.:

Synonyms:(S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate

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Chemical Property of (S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate

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Technology Process of (S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate

There total 1 articles about (S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 403-41-8,101219-73-2,101219-68-5
(R)-1-(4-fluorophenyl)ethan-1-ol

: 82782-85-2
thieno<3,2-b>pyrrole-5-carboxylic acid methyl ester

: 1369487-45-5
(S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 13h;
DOI:10.1021/jm300214e

Reference yield:

: 1369487-45-5
(S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate

: C₁₅H₁₂FNO₂S

Guidance literature:: With potassium hydroxide; In ethanol; water; at 40 ℃; for 16h;
DOI:10.1021/jm300214e

Reference yield:

: 1369487-45-5
(S)-methyl 4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate

: 1369487-31-9
(S)-N-benzyl-1-(4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 16 h / 40 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

2.2: 16 h / 20 °C

3.1: potassium hydroxide / ethanol; water / 16 h / 40 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4.2: 16 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1021/jm300214e