82782-85-2

Basic information

• Product Name: METHYL 4H-THIENO[3,2-B!PYRROLE-5-CARBOXYLATE, 97+%
• Synonyms: METHYL 4H-THIENO[3,2-B!PYRROLE-5-CARBOXYLATE, 97+%;thienopyrrole-5-carboxylic acid Methyl ester
• CAS NO: 82782-85-2
• Molecular Formula: C₈H₇NO₂S
• Molecular Weight: 181.214
• Mol File: 82782-85-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 143-145℃
• Boiling Point: 336.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.402
• Storage Temp.: 2-8°C
• PKA: 14.61±0.30(Predicted)
• CAS DataBase Reference: METHYL 4H-THIENO[3,2-B!PYRROLE-5-CARBOXYLATE, 97+%(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4H-THIENO[3,2-B!PYRROLE-5-CARBOXYLATE, 97+%(82782-85-2)
• EPA Substance Registry System: METHYL 4H-THIENO[3,2-B!PYRROLE-5-CARBOXYLATE, 97+%(82782-85-2)

Safety Data

• Hazardous Substances Data: 82782-85-2(Hazardous Substances Data)

Usage

General Description

METHYL 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE, 97+%, also known as methyl thiophene carboxylate, is a chemical compound with a purity of 97% or higher. It is a heterocyclic compound containing a thieno-pyrrole ring structure with a methyl ester functional group attached to the carboxyl group at the 5-position. This chemical may have various applications in the pharmaceutical, agrochemical, and material science industries due to its unique structure and reactivity. It can be used as a building block for the synthesis of complex organic molecules and may exhibit biological or chemical properties that are beneficial for the development of new drugs or materials.

Upstream product

• 102244-89-3 β-(2-Thienyl-)-α-azidoacrylsaeuremethylester 
• 67-56-1 methanol 
• 39793-31-2 4H-thieno[3,2-b]pyrrole-5-carboxylic acid 
• 74-88-4 methyl iodide 
• 439113-19-6 methyl 2-azido-3-(thiophen-2-yl)acrylate 
• 368442-47-1 3-(tert-butoxycarbonylamino)-2-thiophenecarboxaldehyde 
• 98-03-3 thiophene-2-carbaldehyde 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1816-92-8 Methyl azidoacetate 

Downstream Products

• 1007388-64-8 methyl 6-[(dimethylamino)methyl]-4H-thieno[3,2-b]pyrrole-5-carboxylate 
• 1007388-98-8 methyl 2-[(dimethylamino)methyl]-4H-furo[3,2-b]pyrrole-5-carboxylate 
• 1369487-28-4 (S)-1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(1-phenylethyl)piperidine-4-carboxamide 
• 1369487-29-5 (R)-1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)-N-(1-phenylethyl)piperidine-4-carboxamide 
• 1369487-30-8 (R)-N-benzyl-1-(4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)piperidine-4-carboxamide 
• 1369487-31-9 (S)-N-benzyl-1-(4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)piperidine-4-carboxamide 
• 924643-46-9 4-(4-chlorobenzyl)-4H-thieno[3,2-b] pyrrole-5-carboxylic acid 
• 1163209-26-4 C₂₂H₂₃ClN₂O₃S 
• 1369487-46-6 (R)-ethyl 1-(4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)piperidine-4-carboxylate 
• 1369487-47-7 (S)-ethyl 1-(4-(1-(4-fluorophenyl)ethyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)piperidine-4-carboxylate 
• 903165-63-9 C₂₀H₁₉ClN₂O₃S 
• 902901-29-5 N-benzyl-1-(4-(4-fluorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)piperidine-4-carboxamide 
• 902902-81-2 N-benzyl-1-(4-(4-chlorobenzyl)-4H-thieno[3,2-b]pyrrole-5-carbonyl)piperidine-4-carboxamide 
• 897767-45-2 methyl N-(4-fluoro)benzyl-4H-thieno[3,2-b]pyrrole carboxylate 

Relevant articles and documents

Synthesis of Photochromic 1,2-Dihetarylethene Using Regioselective Acylation of Thienopyrroles

(Matrix Presented) The influence of catalysts, acid chlorides, and solvents in the acylation of methyl 2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate was studied. Conditions for the regioselective acylation processes were found. Thienopyrrole-based photoc

Regioselective acylation of methyl 2-methyl-4H-thieno[3,2-b]pyrrole-5- carboxylate

The influence of catalysts, acid chlorides, and solvents on the acylation of methyl 2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate was studied. The use of AlCl3 allows the regioselective introduction of the acyl group into position 3 to be performed, whereas the acyl group is regioselectively introduced into position 6 of thienopyrrole when SnCl4 is used.

Synthesis and characterization of S,N-heterotetracenes

The synthesis and optoelectronic properties of novel S,N-heterotetracenes consisting of fused heterocyclic thiophene and pyrrole rings are presented. Tetracyclic and benzannulated derivatives with a varying number and sequence of sulfur and nitrogen heteroatoms were synthesized in multistep synthetic routes. A Buchwald-Hartwig amination of brominated precursors, thermolysis of azide precursors, and a Cadogan reaction of nitro-substituted precursors were successfully applied to eventually build-up pyrrole rings to stable and soluble fused systems. The various obtained heteroatom sequences 'SSNS' (SN4), 'SNNS' (SN4''), and 'NSSN' (SN4') allowed for evaluation of structure-property relationships relative to the sulfur analogue tetrathienoacene ('SSSS'). In line with the results for the whole series of S,N-heteroacenes, we find that replacement of sulfur by nitrogen atoms in the tetra- and hexacyclic systems leads to a red-shift in absorption, a decrease in oxidation potential and energy gap. On the other hand, the replacement of a thiophene ring by benzene leads to the opposite effects.

Chemical Evolution of a Bacterial Proteome

We have changed the amino acid set of the genetic code of Escherichia coli by evolving cultures capable of growing on the synthetic noncanonical amino acid L-β-(thieno[3,2-b]pyrrolyl)alanine ([3,2]Tpa) as a sole surrogate for the canonical amino acid L-tryptophan (Trp). A long-term cultivation experiment in defined synthetic media resulted in the evolution of cells capable of surviving Trp→[3,2]Tpa substitutions in their proteomes in response to the 20 899 TGG codons of the E. coli W3110 genome. These evolved bacteria with new-to-nature amino acid composition showed robust growth in the complete absence of Trp. Our experimental results illustrate an approach for the evolution of synthetic cells with alternative biochemical building blocks.