3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide

Base Information

• Chemical Name: 3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide
• CAS No.: 1263133-33-0
• Molecular Formula: C₂₀H₁₃F₃N₄O₂
• Molecular Weight: 398.344
• Mol file: 1263133-33-0.mol

Synonyms:3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide

Chemical Property of 3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide

Chemical Property:

• Density: 1.423-1.45 at 20℃

Purity/Quality:

99.9% ^*data from raw suppliers

TRIFLUMEZOPYRIM 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide

There total 14 articles about 3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-[(5-pyrimidinyl)methyl]-2-pyridinamine (1383916-51-5) + S,S-diethyl 2-(3-(trifluoromethyl)phenyl)propanebis(thioate) → 3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide (1263133-33-0)

Guidance literature:

In chlorobenzene; for 6h; Reflux;

DOI:10.1002/adsc.202100369

Reference yield: 58.0%

N-[(5-pyrimidinyl)methyl]-2-pyridinamine (1383916-51-5) + bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate (1383916-52-6) → 3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide (1263133-33-0)

Guidance literature:

In toluene; at 110 ℃; for 6h;

Reference yield:

N-[(5-pyrimidinyl)methyl]-2-pyridinamine (1383916-51-5) + 2-[3-(trifluoromethyl)phenyl]propanedioyl dichloride (1443330-15-1) → 3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide (1263133-33-0)

Guidance literature:

With triethylamine; In hexane; at 3 - 20 ℃; for 0.5h;

upstream raw materials:

pyrimidine-5-carbaldehyde

m-trifluoromethylphenyl iodide

2-aminopyridine

2-[3-(trifluoromethyl)phenyl]malonic acid-1,3-dimethyl ester