bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate

Base Information

• Chemical Name: bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate
• CAS No.: 1383916-52-6
• Molecular Formula: C₂₂H₉Cl₆F₃O₄
• Molecular Weight: 607.024
• Mol file: 1383916-52-6.mol

Synonyms:bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate

Chemical Property of bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate

There total 10 articles about bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.3%

m-trifluoromethylphenyl iodide (401-81-0) + malonic acid dimethyl ester (108-59-8) + 2,4,6-Trichlorophenol (88-06-2,67471-29-8) → bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate (1383916-52-6)

Guidance literature:

m-trifluoromethylphenyl iodide; malonic acid dimethyl ester; With 2-Picolinic acid; copper(l) iodide; In 1,4-dioxane; for 7.5h; Reflux;

With sodium hydroxide; In methanol; water; at 60 ℃; for 2h;

2,4,6-Trichlorophenol; Further stages;

Reference yield: 61.0%

2-[3-(trifluoromethyl)phenyl]propanedioic acid + 2,4,6-Trichlorophenol (88-06-2,67471-29-8) → bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate (1383916-52-6)

Guidance literature:

2-[3-(trifluoromethyl)phenyl]propanedioic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 6h; Cooling with ice;

2,4,6-Trichlorophenol; In dichloromethane; N,N-dimethyl-formamide; for 12h;

Reference yield: 50.43%

2-[3-(trifluoromethyl)phenyl]malonic acid-1,3-dimethyl ester (138485-29-7) + 2,4,6-Trichlorophenol (88-06-2,67471-29-8) → bis(2,4,6‐trichlorophenyl)-2‐(3‐(trifluoromethyl)phenyl)malonate (1383916-52-6)

Guidance literature:

2-[3-(trifluoromethyl)phenyl]malonic acid-1,3-dimethyl ester; With water; sodium hydroxide; at 60 ℃; for 0.133333h; Inert atmosphere;

With hydrogenchloride; In water; pH=1; Cooling with ice;

2,4,6-Trichlorophenol;

upstream raw materials:

2-[3-(trifluoromethyl)phenyl]malonic acid-1,3-dimethyl ester

2,4,6-Trichlorophenol

m-trifluoromethylphenyl iodide

malonic acid dimethyl ester

Downstream raw materials:

3,4-dihydro-2,4-dioxo-1-(pyrimidin-5-ylmethyl)-3-(α,α,α-trifluoro-m-tolyl)-2H-pyrido[1,2-a]pyrimidin-1-ium-3-ide