3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid

Base Information

Chemical Name:3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid
CAS No.:261364-67-4
Molecular Formula:C₂₃H₃₅NO₈
Molecular Weight:453.533
Hs Code.:

Synonyms:3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid

Suppliers and Price of 3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid

There total 6 articles about 3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 261364-66-3
3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropanal

: 261364-67-4
3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid

Guidance literature:: With sodium dihydrogenphosphate; In acetonitrile; at 0 ℃; for 1h;
DOI:10.1021/jm990498j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 261364-67-4
3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / CHCl₃ / 1.5 h / 20 °C

2: 96 percent / pyridine / CHCl₃ / 25 - 30 °C

3: 28 percent / diisopropylethylamine / CHCl₃ / Heating

4: 82 percent / aq. AcOH / tetrahydrofuran / 1 h / 20 °C

5: 97 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 °C

6: 97 percent / 80percent aq. NaClO₂; NaH₂PO₄ / acetonitrile / 1 h / 0 °C

With pyridine; sodium dihydrogenphosphate; acetic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; chloroform; acetonitrile; 1: Acylation / 2: Acylation / 3: Condensation / 4: desilylation / 5: Oxidation / 6: Oxidation;
DOI:10.1021/jm990498j

Reference yield:

: 139115-91-6
2-(2-tert-butyloxycarbonylaminoethoxy)ethanol

: 261364-67-4
3-(2'-(2''-(2''-Boc-aminoethoxy)ethoxycarbonyloxy)-4',6'-dimethylphenyl)-3,3-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / pyridine / CHCl₃ / 25 - 30 °C

2: 28 percent / diisopropylethylamine / CHCl₃ / Heating

3: 82 percent / aq. AcOH / tetrahydrofuran / 1 h / 20 °C

4: 97 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 °C

5: 97 percent / 80percent aq. NaClO₂; NaH₂PO₄ / acetonitrile / 1 h / 0 °C

With pyridine; sodium dihydrogenphosphate; acetic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; chloroform; acetonitrile; 1: Acylation / 2: Condensation / 3: desilylation / 4: Oxidation / 5: Oxidation;
DOI:10.1021/jm990498j