((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride

Base Information

Chemical Name:((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride
CAS No.:1308869-65-9
Molecular Formula:C₃₅H₂₈ClNP*Cl
Molecular Weight:564.494
Hs Code.:

Synonyms:((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride

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Chemical Property of ((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride

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Technology Process of ((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride

There total 5 articles about ((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308869-98-8
2-chloro-3-(chloromethyl)-6-o-tolylquinoline

: 603-35-0
triphenylphosphine

: 1308869-65-9
((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride

Guidance literature:: In toluene; at 20 ℃; for 64h; Reflux;

Reference yield:

: 103-88-8
4-bromoacetanilide

: 1308869-65-9
((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / Cooling with ice; Sealed tube; Inert atmosphere

1.2: 48.5 h / 75 °C

1.3: Cooling with ice

2.1: ethanol; sodium tetrahydroborate / 0.67 h / 0 - 20 °C

3.1: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 2 h / Reflux

4.1: thionyl chloride / dichloromethane / 0.25 h / 20 °C

5.1: toluene / 64 h / 20 °C / Reflux

With sodium tetrahydroborate; thionyl chloride; ethanol; potassium acetate; trichlorophosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1017464-16-2
(6-bromo-2-chloroquinolin-3-yl)methanol

: 1308869-65-9
((2-chloro-6-o-tolylquinolin-3-yl)methyl)triphenylphosphonium chloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; water / 2 h / Reflux

2: thionyl chloride / dichloromethane / 0.25 h / 20 °C

3: toluene / 64 h / 20 °C / Reflux

With thionyl chloride; potassium acetate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In dichloromethane; water; toluene; acetonitrile;