(R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Base Information

Chemical Name:(R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate
CAS No.:1204671-46-4
Molecular Formula:C₂HF₃O₂*C₁₇H₁₇Cl₂NO
Molecular Weight:436.258
Hs Code.:

Synonyms:(R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Suppliers and Price of (R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

There total 6 articles about (R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204677-52-0
(R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine-1-carboxylic acid t-butyl ester

: 76-05-1
trifluoroacetic acid

: 1204671-46-4
(R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: (R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine-1-carboxylic acid t-butyl ester; With hydrogenchloride; In ethanol; at 20 ℃; for 18h;

trifluoroacetic acid;

Reference yield:

: 1204671-45-3
(R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine

: 76-05-1
trifluoroacetic acid

: 1204671-46-4
(R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: In water; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1204671-46-4
(R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 3 h / 70 °C

3.1: hydrogenchloride / ethanol

4.1: water; acetonitrile

With hydrogenchloride; sodium hydride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.061