(R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate

Base Information

Chemical Name:(R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate
CAS No.:1589541-04-7
Molecular Formula:C₁₈H₁₇ClN₄O₃
Molecular Weight:372.811
Hs Code.:

Synonyms:(R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate

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Chemical Property of (R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate

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Technology Process of (R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate

There total 4 articles about (R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16849-91-5
(R)-(+)-N-α-methylbenzylurea

: 1589541-03-6
(4,6-dichloro-3-cyanopyridin-2-yl)methyl acetate

: 1589541-04-7
(R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate

Guidance literature:: With C₅₁H₄₂ClNOP₂Pd; triethylamine; In tetrahydrofuran; at 50 ℃; for 17h; Sealed tube; Inert atmosphere;

Reference yield:

: 64169-92-2
4-hydroxy-2-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

: 1589541-04-7
(R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 17 h / 90 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / 75 °C / Sealed tube

3: N,N-dimethyl-formamide / 2 h / 20 °C

4: triethylamine; C₅₁H₄₂ClNOP₂Pd / tetrahydrofuran / 17 h / 50 °C / Sealed tube; Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); C₅₁H₄₂ClNOP₂Pd; triethylamine; trichlorophosphate; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1589541-02-5
2-(bromomethyl)-4,6-dichloronicotinonitrile

: 1589541-04-7
(R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 2 h / 20 °C

2: triethylamine; C₅₁H₄₂ClNOP₂Pd / tetrahydrofuran / 17 h / 50 °C / Sealed tube; Inert atmosphere

With C₅₁H₄₂ClNOP₂Pd; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;