64169-92-2

Usage

Uses

Used in Pharmaceutical Synthesis:
1,6-dihydro-4-hydroxy-2-methyl-6-oxonicotinonitrile serves as an intermediate in the production of various drugs, contributing to the development of new medications for different therapeutic areas.
Used in Agrochemical Production:
In agricultural applications, 1,6-dihydro-4-hydroxy-2-methyl-6-oxonicotinonitrile has demonstrated potential as an antifungal agent, helping to protect crops from fungal infections and diseases.
Used in Bioactive Molecule Preparation:
1,6-dihydro-4-hydroxy-2-methyl-6-oxonicotinonitrile also acts as a building block in the preparation of bioactive molecules, which can have various applications in the fields of medicine and biology, including the development of new pharmaceutical agents and the study of biological processes.

InChI:InChI=1/C7H6N2O2/c1-4-5(3-8)6(10)2-7(11)9-4/h2H,1H3,(H2,9,10,11)

Upstream product

• 1118-61-2 3-Aminocrotononitrile 
• 15781-70-1 malonic acid bis-(2,4,6-trichloro-phenyl) ester 
• 19866-98-9 (E/Z)-3-aminoprop-2-enenitrile 
• 763-33-7 (E)-3-aminocrotononitrile 

Downstream Products

• 1185190-81-1 4,6-dichloro-2-methyl-3-cyanopyridine 
• 1589541-04-7 (R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate 
• 1589536-75-3 (R)-1-(3-amino-4-(hydroxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea 
• 1589541-06-9 (R)-1-(4-chloro-5-cyano-6-(methoxymethyl)pyridin-2-yl)-3-(1-phenylethyl)urea 
• 1589536-76-4 (R)-1-(3-amino-4-(methoxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea 
• 1589536-78-6 (R)-1-(3-(ethylamino)-4-(methoxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea 
• 1589536-79-7 (R)-N-(4-(methoxymethyl)-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide 
• 1589541-46-7 (R)-1-(4-chloro-5-cyano-6-methylpyridin-2-yl)-3-(1-phenylethyl)urea 
• 1589541-59-2 (R)-1-(3-amino-4-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea 
• 1589539-44-5 (R)-N-(4-methyl-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide 

Relevant academic research and scientific papers

INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

NOVEL COMPOUNDS THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).

Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-iodopyridin-2(1H)-one type anti-HIV agents

A series of C-5 methyl substituted 4-arylthio- and 4-aryloxy-3-iodopyridin- 2(1H)-ones has been synthesized as new pyridinone analogues for their evaluation as anti-HIV inhibitors. The optimization at the 5-position was developed through an efficient use of the key intermediates 5-ethoxycarbonyl- and 5-cyano-pyridin-2(1H)-ones (14 and 15). Biological studies revealed that several compounds show potent HIV-1 reverse transcriptase inhibitory properties, for example, compounds 93 and 99 are active at 0.6-50 nM against wild type HIV-1 and a panel of major simple/double HIV mutant strains.