6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester
• CAS No.: 129634-94-2
• Molecular Formula: C₂₄H₂₅NO₅S
• Molecular Weight: 439.532

Synonyms:6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester

Chemical Property of 6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester

There total 2 articles about 6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-Cyano-ethylsulfanyl)-6,8-dimethyl-indolizine-1,3-dicarboxylic acid diethyl ester (129169-96-6) + α-bromoacetophenone (70-11-1) → 6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester (129634-94-2)

Guidance literature:

With potassium tert-butylate; Yield given. Multistep reaction; 1.) DMF, room temp., 15 min; 2.) room temp., 1 h;

DOI:10.1248/cpb.38.1527

Reference yield:

2-(2-Ethoxycarbonyl-ethylsulfanyl)-6,8-dimethyl-indolizine-1,3-dicarboxylic acid diethyl ester (129169-99-9) + α-bromoacetophenone (70-11-1) → 6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester (129634-94-2)

Guidance literature:

With potassium tert-butylate; Yield given. Multistep reaction; 1.) DMF, room temp., 15 min; 2.) room temp., 1 h;

DOI:10.1248/cpb.38.1527

Reference yield: 92.0%

6,8-Dimethyl-2-(2-oxo-2-phenyl-ethylsulfanyl)-indolizine-1,3-dicarboxylic acid diethyl ester (129634-94-2) → 2-Benzoyl-3-hydroxy-4,6-dimethyl-1-thia-7a-aza-cyclopenta[a]indene-8-carboxylic acid ethyl ester (129635-57-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1248/cpb.38.1527

upstream raw materials:

2-(2-Cyano-ethylsulfanyl)-6,8-dimethyl-indolizine-1,3-dicarboxylic acid diethyl ester

α-bromoacetophenone

2-(2-Ethoxycarbonyl-ethylsulfanyl)-6,8-dimethyl-indolizine-1,3-dicarboxylic acid diethyl ester

Downstream raw materials:

2-Benzoyl-3-hydroxy-4,6-dimethyl-1-thia-7a-aza-cyclopenta[a]indene-8-carboxylic acid ethyl ester

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