4-[(1S,2R,4S,5S,6R)-5,6-bis{(benzyloxy)methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]morpholine

Base Information

Chemical Name:4-[(1S,2R,4S,5S,6R)-5,6-bis{(benzyloxy)methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]morpholine
CAS No.:1567316-98-6
Molecular Formula:C₂₆H₃₃NO₄
Molecular Weight:423.552
Hs Code.:

Synonyms:4-[(1S,2R,4S,5S,6R)-5,6-bis{(benzyloxy)methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]morpholine

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Chemical Property of 4-[(1S,2R,4S,5S,6R)-5,6-bis{(benzyloxy)methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]morpholine

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Technology Process of 4-[(1S,2R,4S,5S,6R)-5,6-bis{(benzyloxy)methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]morpholine

There total 2 articles about 4-[(1S,2R,4S,5S,6R)-5,6-bis{(benzyloxy)methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 5765-65-1
4-(benzoyloxy)morpholine

: 130156-82-0
(1R*,2R*,3S*,4S*)-2,3-bis(benzyloxymethyl)-7-oxabicyclo[2.2.1]hept-5-ene

: 1567316-98-6
4-[(1S,2R,4S,5S,6R)-5,6-bis{(benzyloxy)methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]morpholine

Guidance literature:: With 1,2-bis(bis(3,5-bis(trifluoromethyl)phenyl)phosphanyl)benzene; copper(l) chloride; lithium tert-butoxide; at 20 ℃; for 48h; enantioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/ol5003219

Reference yield:

: 70677-94-0
1,4-di(benzyloxy)but-2,3-ene

: 1567316-98-6
4-[(1S,2R,4S,5S,6R)-5,6-bis{(benzyloxy)methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: Inert atmosphere

2: 1,2-bis(bis(3,5-bis(trifluoromethyl)phenyl)phosphanyl)benzene; lithium tert-butoxide; copper(l) chloride / 48 h / 20 °C / Schlenk technique; Inert atmosphere

With 1,2-bis(bis(3,5-bis(trifluoromethyl)phenyl)phosphanyl)benzene; copper(l) chloride; lithium tert-butoxide; 1: |Diels-Alder Cycloaddition;
DOI:10.1021/ol5003219