(S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide

Base Information

Chemical Name:(S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide
CAS No.:307949-37-7
Molecular Formula:C₁₉H₂₈N₂O₃
Molecular Weight:332.443
Hs Code.:

Synonyms:(S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide

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Chemical Property of (S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide

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Technology Process of (S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide

There total 4 articles about (S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 151416-38-5
(S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-2-pyrrolidinecarboxamide

: 74-88-4
methyl iodide

: 307949-37-7
(S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide

Guidance literature:: With barium dihydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm000931l

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 307949-37-7
(S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / triethylamine; EEDQ / CHCl₃ / 6 h / Heating

2: 94 percent / Ba(OH)2 / H₂O; dimethylformamide / 12 h / 20 °C

With barium dihydroxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000931l

Reference yield:

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 307949-37-7
(S)-1-(tert-butoxycarbonyl)-N-(2,6-dimethylphenyl)-N-methyl-2-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dioxane; H₂O / 24 h / 20 °C

2: 98 percent / triethylamine; EEDQ / CHCl₃ / 6 h / Heating

3: 94 percent / Ba(OH)2 / H₂O; dimethylformamide / 12 h / 20 °C

With barium dihydroxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000931l