methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate

Base Information

Chemical Name:methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate
CAS No.:1286181-13-2
Molecular Formula:C₁₆H₂₀BrNO₅S
Molecular Weight:418.308
Hs Code.:

Synonyms:methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate

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Chemical Property of methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate

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Technology Process of methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate

There total 3 articles about methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 279-40-3
7-aza-bicyclo[2.2.1]heptane

: 1286180-86-6
(4-bromo-3-methoxy-2-methoxycarbonylphenyl)-methanesulphonic acid sodium

: 1286181-13-2
methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate

Guidance literature:: (4-bromo-3-methoxy-2-methoxycarbonylphenyl)-methanesulphonic acid sodium; With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 75 ℃; for 2h;

7-aza-bicyclo[2.2.1]heptane; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: methyl 3-bromo-2-methoxy-6-methylbenzoate

: 1286181-13-2
methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 3 h / illuminated with a 500W tungsten filament lamp

2.1: sodium sulfite / ethanol; water / 2 h / Reflux

3.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 75 °C

3.2: 18 h / 20 °C

With thionyl chloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium sulfite; 2,2'-azobis(isobutyronitrile); In ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1286179-94-9
methyl 3-bromo-6-bromomethyl-2-methoxybenzoate

: 1286181-13-2
methyl 6-(7-azabicyclo[2.2.1]heptane-7-ylsulphonylmethyl)-3-bromo-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium sulfite / ethanol; water / 2 h / Reflux

2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 75 °C

2.2: 18 h / 20 °C

With thionyl chloride; sodium sulfite; In ethanol; water; N,N-dimethyl-formamide; toluene;