6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Base Information

Chemical Name:6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS No.:1187960-55-9
Molecular Formula:C₁₃H₁₅N₃O₄
Molecular Weight:277.28
Hs Code.:

Synonyms:6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

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Technology Process of 6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

There total 3 articles about 6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1187960-54-8
3-(2-cyanoacetyl)-1-[(2,4-dimethoxyphenyl)methyl]urea

: 1187960-55-9
6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Guidance literature:: With ethanol; sodium ethanolate; at 70 ℃;
DOI:10.1021/ol900169f

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1187960-55-9
6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / water / 1.5 h / 85 °C

2: acetic anhydride / 1.5 h / 70 °C

3: sodium ethanolate / ethanol / 1 h / 70 °C

With sulfuric acid; sodium ethanolate; In ethanol; water; acetic anhydride;
DOI:10.1021/acs.jmedchem.0c02169

Reference yield:

: 296277-76-4
1-(2,4-dimethoxybenzyl)urea

: 1187960-55-9
6-amino-1-[(2,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / 1.5 h / 70 °C

2: sodium ethanolate / ethanol / 1 h / 70 °C

With sodium ethanolate; In ethanol; acetic anhydride;
DOI:10.1021/acs.jmedchem.0c02169