4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine

Base Information

Chemical Name:4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine
CAS No.:1438405-67-4
Molecular Formula:C₂₂H₂₈N₂O₃S₂
Molecular Weight:432.608
Hs Code.:

Synonyms:4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine

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Chemical Property of 4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine

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Technology Process of 4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine

There total 10 articles about 4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.88%

: 1438407-88-5
6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine

: 98-09-9
benzenesulfonyl chloride

: 1438405-67-4
4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine

Guidance literature:: With pyridine; at 25 - 30 ℃; Inert atmosphere;

Reference yield:

: 1178787-97-7
(6-amino-2H-benzo[b][1,4]thiazin-4(3H)-yl)(phenyl)methanone

: 1438405-67-4
4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / water / 0 - 85 °C

1.2: 0 - 80 °C

2.1: potassium iodide; caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C / Inert atmosphere

2.2: 100 - 110 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 - 5 °C / Inert atmosphere

3.2: 25 - 30 °C / Inert atmosphere

4.1: pyridine / 25 - 30 °C / Inert atmosphere

With pyridine; sulfuric acid; caesium carbonate; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 110-89-4
piperidine

: 1438405-67-4
4-(phenylsulfonyl)-6-(3-(piperidin-1-yl)propoxy)-3,4-dihydro-2H-benzo[b][1,4]thiazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / toluene / 0 - 5 °C

1.2: 85 - 95 °C

2.1: potassium iodide; caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 °C / Inert atmosphere

2.2: 100 - 110 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 - 5 °C / Inert atmosphere

3.2: 25 - 30 °C / Inert atmosphere

4.1: pyridine / 25 - 30 °C / Inert atmosphere

With pyridine; caesium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;