3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone

Base Information

Chemical Name:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone
CAS No.:1347656-63-6
Molecular Formula:C₂₄H₂₃F₅N₄O₂S
Molecular Weight:526.53
Hs Code.:

Synonyms:3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone

Suppliers and Price of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone

There total 8 articles about 3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1347656-60-3
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-2-propen-1-one

: 1347656-63-6
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone

Guidance literature:: With ammonium chloride; zinc; In ethanol;

Reference yield:

: 1003320-12-4
1-(chloroacetyl)piperidine-4-carbonitrile

: 1347656-63-6
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / water; N,N-dimethyl-formamide / 8 h / 5 - 10 °C

2: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

3: methanol / 20 °C

4: aluminum oxide / dichloromethane / 20 h / Reflux

5: ammonium chloride; zinc / ethanol

With aluminum oxide; hydrogen sulfide; ammonium chloride; 2,2'-iminobis[ethanol]; potassium hydroxide; zinc; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1003320-13-5
1-(2-chloroacetyl)-N-(1,1-dimethylethyl)-4-piperidinecarboxamide

: 1347656-63-6
3-(2,6-difluorophenyl)-1-[2-[1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-4-piperidinyl]-4-thiazolyl]-1-propanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 1.5 h / 37 - 55 °C

1.2: 10 °C / pH 5.5

2.1: potassium hydroxide / water; N,N-dimethyl-formamide / 8 h / 5 - 10 °C

3.1: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 0.5 h / 50 °C

4.1: methanol / 20 °C

5.1: aluminum oxide / dichloromethane / 20 h / Reflux

6.1: ammonium chloride; zinc / ethanol

With aluminum oxide; hydrogen sulfide; ammonium chloride; 2,2'-iminobis[ethanol]; potassium hydroxide; zinc; trichlorophosphate; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;