1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol

Base Information

Chemical Name:1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol
CAS No.:1350375-89-1
Molecular Formula:C₂₅H₂₅ClN₄OS
Molecular Weight:465.019
Hs Code.:

Synonyms:1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol

Suppliers and Price of 1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol

There total 10 articles about 1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350375-92-6
1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

: 1350375-89-1
1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol

Guidance literature:: With water; sodium hydroxide; In methanol; at 70 ℃; for 1h;

Reference yield:

: 362718-83-0
1-(1,3-thiazol-2-yl)cyclobutanol

: 1350375-89-1
1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

1.2: 16 h

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -78 °C

2.2: 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 70 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

4.2: 0.25 h

5.1: hydrogenchloride / water; tetrahydrofuran; methanol / 8 h / 65 °C

6.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 2 h / 70 °C

7.1: sodium sulfate; acetic acid / tetrahydrofuran / 0.5 h / 20 °C

7.2: 1 h

8.1: sodium hydroxide; water / methanol / 1 h / 70 °C

With hydrogenchloride; water; sodium hydride; sodium hydrogencarbonate; acetic acid; sodium sulfate; sodium hydroxide; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350375-63-1
2-(1-(methoxymethoxy)cyclobutyl)-5-(tributylstannyl)thiazole

: 1350375-89-1
1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 70 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

2.2: 0.25 h

3.1: hydrogenchloride / water; tetrahydrofuran; methanol / 8 h / 65 °C

4.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 2 h / 70 °C

5.1: sodium sulfate; acetic acid / tetrahydrofuran / 0.5 h / 20 °C

5.2: 1 h

6.1: sodium hydroxide; water / methanol / 1 h / 70 °C

With hydrogenchloride; water; sodium hydrogencarbonate; acetic acid; sodium sulfate; sodium hydroxide; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;