1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

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Chemical Name:1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol
CAS No.:1350375-92-6
Molecular Formula:C₃₂H₃₁ClN₄O₃S₂
Molecular Weight:619.208
Hs Code.:

Synonyms:1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

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Chemical Property of 1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

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Technology Process of 1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

There total 10 articles about 1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 1350375-91-5
4-(5-chloro-4-(2-(1-hydroxycyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)benzaldehyde

: 1350375-92-6
1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

Guidance literature:: pyrrolidine; 4-(5-chloro-4-(2-(1-hydroxycyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)benzaldehyde; With acetic acid; sodium sulfate; In tetrahydrofuran; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 1h;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1350375-92-6
1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

1.2: 1 h

2.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 70 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

3.2: 0.25 h

4.1: hydrogenchloride / water; tetrahydrofuran; methanol / 8 h / 65 °C

5.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 2 h / 70 °C

6.1: sodium sulfate; acetic acid / tetrahydrofuran / 0.5 h / 20 °C

6.2: 1 h

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; acetic acid; sodium sulfate; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350375-63-1
2-(1-(methoxymethoxy)cyclobutyl)-5-(tributylstannyl)thiazole

: 1350375-92-6
1-(5-(5-chloro-2-(4-(pyrrolidin-1-ylmethyl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 70 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

2.2: 0.25 h

3.1: hydrogenchloride / water; tetrahydrofuran; methanol / 8 h / 65 °C

4.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 2 h / 70 °C

5.1: sodium sulfate; acetic acid / tetrahydrofuran / 0.5 h / 20 °C

5.2: 1 h

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; sodium sulfate; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;