N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide

Base Information

• Chemical Name: N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide
• CAS No.: 136061-02-4
• Molecular Formula: C₁₃H₁₆BrNO₂
• Molecular Weight: 298.18
• Mol file: 136061-02-4.mol

Synonyms:N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide

Chemical Property of N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide

There total 3 articles about N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-2-methyl-cyclopropanecarboxylic acid ethyl ester (89892-99-9) → N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide (136061-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃, H₂O / methanol / 48 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 1 h / Ambient temperature

3: tetrahydrofuran / 3 h

With water; potassium carbonate; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/ja00019a040

Reference yield:

trans-2-bromo-2-methylcyclopropanecarboxylic acid (136061-00-2,136061-01-3,136171-96-5) → N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide (136061-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 1 h / Ambient temperature

2: tetrahydrofuran / 3 h

With triethylamine; In tetrahydrofuran;

DOI:10.1021/ja00019a040

Reference yield:

C10H14O4 + C10H15BrO4 → N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1S,2R)-2-bromo-2-methylcyclopropanecarboxamide (136171-95-4) + N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,2S)-2-bromo-2-methylcyclopropanecarboxamide (136061-02-4)

Guidance literature:

In tetrahydrofuran; for 3h;

DOI:10.1021/ja00019a040

upstream raw materials:

2-bromo-2-methyl-cyclopropanecarboxylic acid ethyl ester

trans-2-bromo-2-methylcyclopropanecarboxylic acid

Downstream raw materials:

(1R,2S)-<α-(2)H>-2-bromo-2-methylcyclopropanecarboxaldehyde

(1R,2S)-2-bromo-2-methylcyclopropanemethanol

(1R,2S)-2-bromo-2-methylcyclopropanecarboxaldehyde

N-<(R)-1'-phenyl-2'-hydroxyethyl>-(1R,αS)-<α-(2)H>methylenecyclopropaneacetamide