(S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide

Base Information

Chemical Name:(S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide
CAS No.:1360631-84-0
Molecular Formula:C₂₄H₂₅N₃O₃S
Molecular Weight:435.547
Hs Code.:

Synonyms:(S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide

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Technology Process of (S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide

There total 5 articles about (S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1360631-78-2
(2S)-2-(2-aminophenylamino)-3-(1H-indol-3-yl)propan-1-ol

: 98-59-9
p-toluenesulfonyl chloride

: 1360631-84-0
(S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide

Guidance literature:: With pyridine; at 0 ℃; for 12h;
DOI:10.1039/c1ob06304a

Reference yield:

: 1203586-50-8
(2S)-3-(1H-indol-3-yl)-2-(2-nitrophenylamino)propionic acid methyl ester

: 1360631-84-0
(S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

2: pyridine / 12 h / 0 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1039/c1ob06304a

Reference yield:

: 1203586-29-1
C₁₇H₁₅N₃O₄

: 1360631-84-0
(S)-N-{2-[1-hydroxymethyl-2-(1H-indol-3-yl)ethylamino]phenyl}-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 0 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

3: pyridine / 12 h / 0 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran;
DOI:10.1039/c1ob06304a