(6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Chemical Name:(6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
CAS No.:1202941-72-7
Molecular Formula:C₁₈H₁₆F₃N₅O₅
Molecular Weight:439.351
Hs Code.:

Synonyms:(6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Chemical Property of (6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Technology Process of (6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

There total 4 articles about (6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 187235-08-1
(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol

: 1202942-21-9
5-(bromomethyl)-1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole

: 1202941-72-7
(6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h;
DOI:10.1021/jm901378u

Reference yield:

: 103962-05-6
1-iodo-4-(trifluoromethoxy)benzene

: 1202941-72-7
(6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate; copper(l) iodide / bis(triphenylphosphine)palladium(II) dichloride / water; tetrahydrofuran / 48 h / 20 °C

2: hydrogenchloride / tetrahydrofuran / 16 h / 80 °C

3: phosphorus tribromide / diethyl ether / 0 - 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C

With hydrogenchloride; copper(l) iodide; phosphorus tribromide; sodium hydride; sodium hydrogencarbonate; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 1202942-19-5
1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole

: 1202941-72-7
(6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran / 16 h / 80 °C

2: phosphorus tribromide / diethyl ether / 0 - 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C

With hydrogenchloride; phosphorus tribromide; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;