1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole

Base Information

• Chemical Name: 1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole
• CAS No.: 1202942-19-5
• Molecular Formula: C₁₇H₁₉F₃N₂O₃
• Molecular Weight: 356.345

Synonyms:1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole

Chemical Property of 1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole

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Technology Process of 1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole

There total 2 articles about 1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-(tetrahydropyran-2'-yloxy)propyne (6089-04-9) + carbon monoxide (201230-82-2) + methylhydrazine sulfuric acid (302-15-8) + 1-iodo-4-(trifluoromethoxy)benzene (103962-05-6) → 1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole (1202942-19-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 48h; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/jm901378u

Reference yield: 64.0%

3-(tetrahydropyran-2'-yloxy)propyne (6089-04-9) + carbon monoxide (201230-82-2) + 1-iodo-4-(trifluoromethoxy)benzene (103962-05-6) → 1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole (1202942-19-5)

Guidance literature:

With copper(l) iodide; sodium hydrogencarbonate; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; water; at 20 ℃; for 48h;

Reference yield: 38.0%

1-methyl-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole (1202942-19-5) → {1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methanol (864427-07-6)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 80 ℃; for 16h;

DOI:10.1021/jm901378u

upstream raw materials:

3-(tetrahydropyran-2'-yloxy)propyne

carbon monoxide

methylhydrazine sulfuric acid

1-iodo-4-(trifluoromethoxy)benzene

Downstream raw materials:

{1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methanol

(6S)-6-({1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

5-(bromomethyl)-1-methyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazole

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