1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene

Base Information

Chemical Name:1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene
CAS No.:1592848-00-4
Molecular Formula:C₂₅H₁₈F₆N₂S
Molecular Weight:492.488
Hs Code.:

Synonyms:1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene

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Chemical Property of 1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene

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Technology Process of 1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene

There total 8 articles about 1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1367867-13-7
1,2-dimethyl-3-bromine-7-azaindole

: 308255-22-3
1-[2-methyl-5-phenyl-3-thienyl]heptafluorocyclopentene

: 1592848-00-4
1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene

Guidance literature:: 1,2-dimethyl-3-bromine-7-azaindole; With n-butyllithium; In tetrahydrofuran; hexane; at -78.16 ℃; for 0.5h; Inert atmosphere;

1-[2-methyl-5-phenyl-3-thienyl]heptafluorocyclopentene; In tetrahydrofuran; hexane; at -78.16 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.dyepig.2014.03.003

Reference yield:

: 271-63-6
7-Azaindole

: 1592848-00-4
1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane / 0.17 h / -0.16 °C

1.2: 12.33 h / 0 - 20 °C

2.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -25.16 °C / Inert atmosphere

2.2: 10 h / 20 - 25 °C / Inert atmosphere

3.1: N-Bromosuccinimide; tetrachloromethane / 12 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -0.16 °C

4.2: 24 h / -0.16 °C

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78.16 °C / Inert atmosphere

5.2: 2 h / -78.16 °C / Inert atmosphere

With tetrachloromethane; N-Bromosuccinimide; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.dyepig.2014.03.003

Reference yield:

: 143141-23-5
1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine

: 1592848-00-4
1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -25.16 °C / Inert atmosphere

1.2: 10 h / 20 - 25 °C / Inert atmosphere

2.1: N-Bromosuccinimide; tetrachloromethane / 12 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -0.16 °C

3.2: 24 h / -0.16 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78.16 °C / Inert atmosphere

4.2: 2 h / -78.16 °C / Inert atmosphere

With tetrachloromethane; N-Bromosuccinimide; n-butyllithium; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.dyepig.2014.03.003