Technology Process of 1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene
There total 8 articles about 1-(1,2-dimethyl-7-azaindole-3-yl)-2-(2-methyl-5-phenyl-3-thienyl)perfluorocyclopentene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,2-dimethyl-3-bromine-7-azaindole;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78.16 ℃;
for 0.5h;
Inert atmosphere;
1-[2-methyl-5-phenyl-3-thienyl]heptafluorocyclopentene;
In
tetrahydrofuran; hexane;
at -78.16 ℃;
for 2h;
Inert atmosphere;
DOI:10.1016/j.dyepig.2014.03.003
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane / 0.17 h / -0.16 °C
1.2: 12.33 h / 0 - 20 °C
2.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -25.16 °C / Inert atmosphere
2.2: 10 h / 20 - 25 °C / Inert atmosphere
3.1: N-Bromosuccinimide; tetrachloromethane / 12 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -0.16 °C
4.2: 24 h / -0.16 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78.16 °C / Inert atmosphere
5.2: 2 h / -78.16 °C / Inert atmosphere
With
tetrachloromethane; N-Bromosuccinimide; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; sodium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.dyepig.2014.03.003
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -25.16 °C / Inert atmosphere
1.2: 10 h / 20 - 25 °C / Inert atmosphere
2.1: N-Bromosuccinimide; tetrachloromethane / 12 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -0.16 °C
3.2: 24 h / -0.16 °C
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78.16 °C / Inert atmosphere
4.2: 2 h / -78.16 °C / Inert atmosphere
With
tetrachloromethane; N-Bromosuccinimide; n-butyllithium; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.dyepig.2014.03.003
