2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide

Base Information

Chemical Name:2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide
CAS No.:1622242-69-6
Molecular Formula:C₂₈H₂₂F₂N₂O₄S
Molecular Weight:520.556
Hs Code.:

Synonyms:2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide

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Technology Process of 2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide

There total 13 articles about 2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1622243-03-1
(6-amino-3-(3-fluorophenyl)pyridin-2-yl)(4-fluorophenyl)methanone

: 1622242-69-6
2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 12h;

Reference yield:

: 5327-33-3
2-acetylamino-6-methylpyridine

: 1622242-69-6
2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium permanganate / water / 3 h / 75 °C

1.2: 12 h / Reflux

2.1: bromine; sodium carbonate / acetic acid / 5 h / 20 °C

3.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,3-dioxane / 2 h / 90 °C

4.1: water; lithium hydroxide monohydrate / ethanol / 2 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

6.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 12 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium permanganate; lithium hydroxide monohydrate; water; bromine; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,3-dioxane; diethyl ether; ethanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1214359-92-8
methyl 6-amino-3-(3-fluorophenyl)picolinate

: 1622242-69-6
2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-fluorobenzoyl)-5-(3-fluorophenyl)pyridin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide monohydrate / ethanol / 2 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

3: tetrahydrofuran; diethyl ether / 0.5 h / 0 - 20 °C / Inert atmosphere

4: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 12 h / 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;