4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide

Base Information

Chemical Name:4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide
CAS No.:406232-64-2
Molecular Formula:C₁₉H₁₂ClFN₂O₅S
Molecular Weight:434.832
Hs Code.:

Synonyms:4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide

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Chemical Property of 4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide

Chemical Property:

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Technology Process of 4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide

There total 9 articles about 4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 5731-10-2
4'-fluoro-biphenyl-4-carboxylic acid

: 97-09-6
4-Chloro-3-nitrobenzenesulfonamide

: 406232-64-2
4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm050754u

Reference yield:

: 5798-75-4
Ethyl 4-bromobenzoate

: 406232-64-2
4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; ethanol / 0.25 h / 20 °C

2: 94 percent / aq. NaOH / tetrahydrofuran; methanol / 20 °C

3: 57 percent / EDC; DMAP / CH₂Cl₂ / 24 h / 20 °C

With dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; 1: Suzuki coupling;
DOI:10.1021/jm0507532

Reference yield:

: 97-08-5
3-nitro-4-chlorosulfonyl chloride

: 406232-64-2
4-chloro-N-(4′-fluorobiphenyl-4-ylcarbonyl)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / aq. NH₄OH / diethyl ether / 0.5 h / 20 °C

2: 57 percent / EDC; DMAP / CH₂Cl₂ / 24 h / 20 °C

With dmap; ammonium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In diethyl ether; dichloromethane;
DOI:10.1021/jm0507532