97-08-5

Basic information

• Product Name: 4-Chloro-3-nitrobenzenesulfonyl chloride
• Synonyms: 3-NITRO-4-CHLOROBENZENESULFONYL CHLORIDE;3-NITRO-4-CHLOROBENZENSULFONYL CHLORIDE;4-CHLORO-3-NITROBENZENE-1-SULFONYL CHLORIDE;4-CHLORO-3-NITROBENZENESULFONYL CHLORIDE;4-CHLORO-3-NITROBENZENESULPHONYL CHLORIDE;2-CHLORO-1-NITROBENZENE-5-SULFONYL CHLORIDE;YELLOW SULFON CHLORIDE;4-chloro-3-nitro-benzenesulfonylchlorid
• CAS NO: 97-08-5
• Molecular Formula: C₆H₃Cl₂NO₄S
• Molecular Weight: 256.06
• EINECS: 202-558-2
• Product Categories: Intermediates of Dyes and Pigments;Benzene derivates;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;NULL
• Mol File: 97-08-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 59-60 °C(lit.)
• Boiling Point: 356°C (rough estimate)
• Flash Point: 169.1 °C
• Appearance: Light brown/Crystalline Powder
• Density: 1.696 (estimate)
• Vapor Pressure: 6.17E-05mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Toluene
• Sensitive: Moisture Sensitive
• BRN: 1978600
• CAS DataBase Reference: 4-Chloro-3-nitrobenzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-nitrobenzenesulfonyl chloride(97-08-5)
• EPA Substance Registry System: 4-Chloro-3-nitrobenzenesulfonyl chloride(97-08-5)

Safety Data

• Hazard Codes: C
• Statements: 34-29-14
• Safety Statements: 26-27-28-36/37/39-45-8-30-22
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 97-08-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 97-08-5 differently. You can refer to the following data:
1. 4-Chloro-3-nitrobenzenesulfonyl Chloride is used in the synthesis of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones which increases melanin synthesis in murine B16 cells.
2. 4-Chloro-3-nitrobenzenesulfonyl chloride can be used: In the preparation of functionalized 1H-indenes via copper-catalyzed arylative cyclization.As a precursor in the synthesis of N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives that show potential nematicidal activity.As a key starting material in the synthesis of sulfonamide analogs of ferrostatin-1 (fer-1), which possess good ferroptosis inhibition property.In the synthesis of 4-chloro-3-nitrobenzene thiol.

InChI:InChI=1/C6H3Cl2NO4S/c7-5-2-1-4(14(8,12)13)3-6(5)9(10)11/h1-3H

Upstream product

• 121-18-6 3-nitro-4-chlorobenzenesulfonic acid 
• 88-73-3 2-Chloronitrobenzene 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 17691-19-9 4-chloro-3-nitrobenzenesulphonic acid sodium salt 
• 7790-94-5 chlorosulfonic acid 
• 119-00-6 2-nitro-1,4-benzenedisulfonic acid 
• 10026-13-8 phosphorus pentachloride 
• 98-66-8 4-chloro-benzenesulfonic acid 
• 6671-49-4 4-chloro-3-nitro-benzenesulfonic acid ; potassium-salt 
• 635-22-3 4-Chloro-3-nitroaniline 
• 5329-14-6 aminosulfonic acid 

Downstream Products

• 53162-43-9 1-(4-chloro-3-nitro-benzenesulfonyl)-piperidine 
• 94428-01-0 4-chloro-3-nitro-benzenesulfonic acid-[2]pyridylamide 
• 43001-57-6 3-nitro-4-chloro-benzene sulfonic acid phenyl ester 
• 6655-80-7 4-chloro-3-nitrobenzenesulfonylhydrazine 
• 35964-48-8 1,1'-disulphanediylbis(4-chloro-3-nitrobenzene) 
• 97-09-6 4-Chloro-3-nitrobenzenesulfonamide 
• 101251-02-9 N-(3-nitro-4-chlorophenylsulfonyl)ethanolamine 
• 137-47-3 4-chloro-N,N-dimethyl-3-nitrobenzenesulfonamide 
• 58596-13-7 4-(4-chloro-3-nitrobenzenesulfonamido)-1-hydroxy-N-[4-(2,4-di-tert-pentylphenoxy)-butyl]-2-naphthamide 
• 1026303-96-7 {4-[2-(4-Chloro-3-nitro-benzenesulfonylamino)-ethylsulfanyl]-phenoxy}-acetic acid ethyl ester 
• 71799-32-1 4-chloro-3-nitro-benzenesulfinic acid 
• 115314-16-4 (2R)-glycidyl 4-chloro-3-nitrobenzenesulfonate 
• 115314-19-7 (2S)-glycidyl 4-chloro-3-nitrobenzenesulfonate 
• 135685-03-9 N-<2-<<(1,1-dimethylethoxy)carbonyl>amino>ethyl>-4-hydroxy-3-nitrobenzenesulfonamide 

Relevant articles and documents

Amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide

An amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide is disclosed. According to the method, 4-halogeno-benzenesulfonyl chloride which is used as a raw material undergoes nitration to prepare 3-nitro-4-halogeno-benzenesulfonyl chloride; and after aminolysis, 3-nitro-4-halogeno-benzenesulfonamide is prepared. By the synthesis method provided by the invention, the synthesis route by the adoption of chlorosulfonic acid is changed, and production safety is remarkably raised. The reaction condition is milder and is easy for production control. Thus, mass production of the compound is easier to implement and realize.

THROMBIN FUNCTION COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEM

This invention relates to new chemical compounds, application of these compound as thrombin inhibitors, and pharmaceutical compositions based on them, and can be used to treat and prevent thrombin-dependent thromboembolic events, and in research.

Tetrahydropyran derivatives

A novel tetrahydropyran derivative which has an excellent apo B-related lipoprotein secretion-inhibiting activity of the following general formula (I) or a salt thereof: R8 and R9 are the same or different and each represents H, lower alkyl, R30-lower alkyl-, R31R32N-, optionally- substituted hetero ring, or R33R34R35C-; R8 and R9 may together form optionally-substituted hetero ring-; R30 represents optionally-substituted aryl, optionally-substituted hetero ring-, or lower alkyl-O-; R31 represents optionally-substituted aryl, or optionally-substituted hetero ring-; R33 represents HO-lower alkyl-, or optionally-substituted hetero ring-lower alkyl-; R34 represents optionally-substituted aryl-.