3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

Base Information

Chemical Name:3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
CAS No.:185259-85-2
Molecular Formula:C₂₃H₂₇N₃O₂
Molecular Weight:377.486
Hs Code.:
European Community (EC) Number:633-752-9
Wikidata:Q76323634
Pharos Ligand ID:NPNZ24WLU6K1
ChEMBL ID:CHEMBL344127
Mol file:185259-85-2.mol

Synonyms:3-(3-(2-dimethylaminoethyl)-H-indol-5-yl)-N-(4-methoxybenzyl)acrylamide;GR 46611;GR46611

Suppliers and Price of 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GR46611
10mg
$ 180.00

Tocris
GR46611
10
$ 130.00

Tocris
GR46611
50
$ 544.00

American Custom Chemicals Corporation
3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE 95.00%
50MG
$ 1199.42

American Custom Chemicals Corporation
3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE 95.00%
10MG
$ 702.19

AHH
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide 98%
0.05g
$ 460.00

Total 9 raw suppliers

Chemical Property of 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

Chemical Property:

Vapor Pressure:1.43E-16mmHg at 25°C
Boiling Point:645.9°Cat760mmHg
Flash Point:344.4°C
PSA：57.36000
Density:1.168g/cm³
LogP:4.00110
Storage Temp.:2-8°C
Solubility.:DMSO: 28 mg/mL, soluble
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:377.21032711
Heavy Atom Count:28
Complexity:514

Purity/Quality:

99%, ^*data from raw suppliers

GR46611 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCC1=CNC2=C1C=C(C=C2)C=CC(=O)NCC3=CC=C(C=C3)OC
Isomeric SMILES:CN(C)CCC1=CNC2=C1C=C(C=C2)/C=C/C(=O)NCC3=CC=C(C=C3)OC
Uses GR 46611is a 5-HT1D agonist.

Technology Process of 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

There total 4 articles about 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 70875-53-5
N-(4-methoxybenzyl)-acrylamide

: 3-(dimethylaminoethyl)-5-[(trifluoromethanesulfonyl)oxy]indole

: 185259-85-2
GR 46611

Guidance literature:: With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In N,N-dimethyl-formamide; at 85 ℃; for 18h;
DOI:10.1021/jm9604890

Reference yield:

: 70875-53-5
N-(4-methoxybenzyl)-acrylamide

: 17274-65-6
5-bromo-3-[2-(N,N-dimethylamino)ethyl]-1H-indole

: 185259-85-2
GR 46611

Guidance literature:: With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

Reference yield:

: 487-93-4
bufotenin

: 185259-85-2
GR 46611

Guidance literature:: Multi-step reaction with 2 steps

1: 93 mg / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

2: 44 percent / Pd(OAc)2, 1,3-bis(diphenylphosphino)propane, Et₃N / dimethylformamide / 18 h / 85 °C

With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9604890