4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one

Base Information

• Chemical Name: 4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one
• CAS No.: 1335015-90-1
• Molecular Formula: C₁₈H₁₄N₆O₃S₂
• Molecular Weight: 426.48
• Mol file: 1335015-90-1.mol

Synonyms:4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one

Chemical Property of 4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one

There total 5 articles about 4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-2H-1,4-benzothiazin-3(4H)-one (1335015-79-6) + 4-nitrobenzaldehdye (555-16-8) → 4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one (1335015-90-1)

Guidance literature:

With sulfuric acid; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2011.06.010

Reference yield:

2-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]thiazin-4-yl)acetic acid (100637-60-3) → 4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one (1335015-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 h / 140 °C / Neat (no solvent)

2: sulfuric acid / N,N-dimethyl-formamide / 6 h / 20 °C

With sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.06.010

Reference yield:

2H-1,4-benzothiazin-3-one (5325-20-2) → 4-{[4-(p-nitro-benzylideneamino)-5-sulfanyl-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-one (1335015-90-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Reflux

2: potassium hydroxide / ethanol; water / 24 h / 20 °C

3: 3 h / 140 °C / Neat (no solvent)

4: sulfuric acid / N,N-dimethyl-formamide / 6 h / 20 °C

With sulfuric acid; potassium carbonate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.06.010

upstream raw materials:

4-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-2H-1,4-benzothiazin-3(4H)-one

4-nitrobenzaldehdye

2H-1,4-benzothiazin-3-one

2-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]thiazin-4-yl)acetic acid

Downstream raw materials:

C₂₄H₂₆N₈O₃S₂

C₂₃H₂₃N₇O₄S₂

C₂₄H₂₅N₇O₃S₂