5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-methyl-Benzoic acid methyl ester

Base Information

Chemical Name:5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-methyl-Benzoic acid methyl ester
CAS No.:1184301-84-5
Molecular Formula:C₁₅H₂₁NO₄
Molecular Weight:279.336
Hs Code.:
Mol file:1184301-84-5.mol

Synonyms:methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-methylbenzoate

Suppliers and Price of 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-methyl-Benzoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl5-(((tert-butoxycarbonyl)amino)methyl)-2-methylbenzoate 97%
1g
$ 474.00

Total 5 raw suppliers

Chemical Property of 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-methyl-Benzoic acid methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methyl5-(((tert-butoxycarbonyl)amino)methyl)-2-methylbenzoate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-methyl-Benzoic acid methyl ester

There total 5 articles about 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-2-methyl-Benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 103261-68-3
5-cyano-2-methylbenzoic acid methyl ester

: 1184301-84-5
methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-methylbenzoate

Guidance literature:: With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 - 23 ℃; for 2.25h;
DOI:10.1021/jm900611t

Reference yield:

: 1975-52-6
5-nitro-o-toluic acid

: 1184301-84-5
methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 0 °C / Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 23 °C

3.1: hydrogenchloride; sodium nitrite / water / 0 - 23 °C / Cooling with ice

4.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0 - 23 °C

4.2: 0.25 h

With hydrogenchloride; methanol; sodium tetrahydroborate; thionyl chloride; nickel(II) chloride hexahydrate; hydrogen; sodium nitrite; palladium 10% on activated carbon; In water; ethyl acetate;

Reference yield:

: 77324-87-9
methyl 2-methyl-5-nitrobenzoate

: 1184301-84-5
methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 23 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 - 23 °C / Cooling with ice

3.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0 - 23 °C

3.2: 0.25 h

With hydrogenchloride; methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; hydrogen; sodium nitrite; palladium 10% on activated carbon; In water; ethyl acetate;