Technology Process of 5-(tert-Butoxycarbonylamino-methyl)-2-methyl-benzoic acid
There total 5 articles about 5-(tert-Butoxycarbonylamino-methyl)-2-methyl-benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 5-(((tert-butoxycarbonyl)amino)methyl)-2-methylbenzoate;
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; water;
at 0 - 23 ℃;
With
hydrogenchloride; sodium hydrogencarbonate;
In
water;
DOI:10.1021/jm900611t
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / 0 °C / Reflux
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 23 °C
3.1: hydrogenchloride; sodium nitrite / water / 0 - 23 °C / Cooling with ice
4.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0 - 23 °C
4.2: 0.25 h
5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0 - 23 °C
5.2: pH 4
With
hydrogenchloride; methanol; sodium tetrahydroborate; thionyl chloride; nickel(II) chloride hexahydrate; lithium hydroxide monohydrate; water; hydrogen; sodium nitrite;
palladium 10% on activated carbon;
In
tetrahydrofuran; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 23 °C
2.1: hydrogenchloride; sodium nitrite / water / 0 - 23 °C / Cooling with ice
3.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0 - 23 °C
3.2: 0.25 h
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0 - 23 °C
4.2: pH 4
With
hydrogenchloride; methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; lithium hydroxide monohydrate; water; hydrogen; sodium nitrite;
palladium 10% on activated carbon;
In
tetrahydrofuran; water; ethyl acetate;
