4-((2S)-morpholin-2-yl)benzonitrile hydrochloride

Base Information

Chemical Name:4-((2S)-morpholin-2-yl)benzonitrile hydrochloride
CAS No.:1035374-47-0
Molecular Formula:C₁₁H₁₂N₂O*ClH
Molecular Weight:224.69
Hs Code.:

Synonyms:4-((2S)-morpholin-2-yl)benzonitrile hydrochloride

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Chemical Property of 4-((2S)-morpholin-2-yl)benzonitrile hydrochloride

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Technology Process of 4-((2S)-morpholin-2-yl)benzonitrile hydrochloride

There total 9 articles about 4-((2S)-morpholin-2-yl)benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 1035374-46-9
4-{(2S)-4-[(1R)-1-phenylethyl]morpholin-2-yl}benzonitrile

: 1035374-47-0
4-((2S)-morpholin-2-yl)benzonitrile hydrochloride

Guidance literature:: In methanol; 1,2-dichloro-ethane; at 20 ℃; for 8h; Heating / reflux;

Reference yield:

: 40805-50-3
4-(2-chloroacetyl)benzenecarbonitrile

: 1035374-47-0
4-((2S)-morpholin-2-yl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF; potassium hydroxide; (S)-Corey-Bakshi-Shibata oxazaborolidine / water; diethyl ether / -30 °C

2.1: potassium hydroxide / water; diethyl ether / 20 °C

3.1: 80 °C

4.1: sodium hydroxide / dichloromethane; water / 20 °C

5.1: potassium hydroxide / isopropyl alcohol / 20 °C

6.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran / 20 °C

7.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 20 °C

7.2: Reflux

With lithium borohydride; chloro-trimethyl-silane; borane-THF; carbonochloridic acid 1-chloro-ethyl ester; potassium hydroxide; sodium hydroxide; (S)-Corey-Bakshi-Shibata oxazaborolidine; In tetrahydrofuran; diethyl ether; dichloromethane; water; isopropyl alcohol;
DOI:10.1016/j.bmcl.2013.09.020