6-(2,6-dichlorophenyl)-N₂-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Base Information

• Chemical Name: 6-(2,6-dichlorophenyl)-N₂-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine
• CAS No.: 179343-21-6
• Molecular Formula: C₂₁H₂₆Cl₂N₆
• Molecular Weight: 433.384
• Mol file: 179343-21-6.mol

Synonyms:6-(2,6-dichlorophenyl)-N₂-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Chemical Property of 6-(2,6-dichlorophenyl)-N₂-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2,6-dichlorophenyl)-N₂-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

There total 4 articles about 6-(2,6-dichlorophenyl)-N₂-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-(diethylamino)butylamine (27431-62-5) + 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine (26752-70-5) → 6-(2,6-dichlorophenyl)-N2-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (179343-21-6)

Guidance literature:

With aminosulfonic acid; at 150 ℃; for 28h;

DOI:10.1021/jm970367n

Reference yield:

ethanol (64-17-5) + aminosulfonic acid (5329-14-6) + N'-butyl-N,N-diethyl-hydrazine + 2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine (26752-70-5) → 6-(2,6-dichlorophenyl)-N2-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (179343-21-6)

Guidance literature:

With sodium chloride; sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

2,4-diamino-5-pyrimidinecarboxaldehyde (20781-06-0) → 6-(2,6-dichlorophenyl)-N2-(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (179343-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaH / 2-ethoxy-ethanol / 4 h / Heating

2: 64 percent / sulfamic acid / 28 h / 150 °C

With aminosulfonic acid; sodium hydride; In 2-ethoxy-ethanol;

DOI:10.1021/jm970367n

upstream raw materials:

4-(diethylamino)butylamine

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]-pyrimidine

2,4-diamino-5-pyrimidinecarboxaldehyde

2,6-dichlorophenylacetonitrile