2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide

Base Information

• Chemical Name: 2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide
• CAS No.: 1338699-03-8
• Molecular Formula: C₂₃H₂₇NO₆
• Molecular Weight: 413.47
• Mol file: 1338699-03-8.mol

Synonyms:2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide

Chemical Property of 2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide

There total 2 articles about 2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(E)-2-(3-phenylprop-2-enoyl)pyridine-1-oxide (942129-14-8) + diisopropyl malonate (13195-64-7) → 2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide (1338699-03-8) + 2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide

Guidance literature:

(E)-2-(3-phenylprop-2-enoyl)pyridine-1-oxide; With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; In dichloromethane; at -25 - 20 ℃; Inert atmosphere;

diisopropyl malonate; With triethylamine; In dichloromethane; at -25 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol202405v

Reference yield:

diisopropyl malonate (13195-64-7) + 2'-benzylidene-2-acetylpyridine N-oxide (1059698-88-2) → 2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide (1338699-03-8) + 2-(5-isopropoxy-4-(isopropoxycarbonyl)-5-oxo-3-phenylpentanoyl)pyridine 1-oxide

Guidance literature:

With C₆₄H₇₉N₂O₄Sc; In dichloromethane; at 25 ℃; for 50h; Overall yield = 65 %; enantioselective reaction; Molecular sieve; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetasy.2016.07.014

upstream raw materials:

(E)-2-(3-phenylprop-2-enoyl)pyridine-1-oxide

diisopropyl malonate

2'-benzylidene-2-acetylpyridine N-oxide