2-phenyl-3-(thiophen-2-yl)-1H-indole

Base Information

• Chemical Name: 2-phenyl-3-(thiophen-2-yl)-1H-indole
• CAS No.: 55654-00-7
• Molecular Formula: C₁₈H₁₃NS
• Molecular Weight: 275.374
• Mol file: 55654-00-7.mol

Synonyms:2-phenyl-3-(thiophen-2-yl)-1H-indole

Chemical Property of 2-phenyl-3-(thiophen-2-yl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-phenyl-3-(thiophen-2-yl)-1H-indole

There total 7 articles about 2-phenyl-3-(thiophen-2-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 2-phenyl-3-(thiophen-2-yl)-1H-indole (55654-00-7)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In 1,4-dioxane; at 100 ℃; for 24h;

Reference yield: 78.0%

2-Iodothiophene (3437-95-4,149762-92-5) + iodobenzene (591-50-4) + N-(2-ethynylphenyl)-2,2,2-trifluoroacetamide (143360-93-4) → 2-phenyl-3-(thiophen-2-yl)-1H-indole (55654-00-7)

Guidance literature:

iodobenzene; N-(2-ethynylphenyl)-2,2,2-trifluoroacetamide; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 9h; Inert atmosphere; Schlenk technique;

2-Iodothiophene; In N,N-dimethyl-formamide; at 70 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1039/d0ob02295k

Reference yield: 57.0%

thiophene-2-sulfonyl chloride (16629-19-9) + 1-azido-2-(phenylethynyl)benzene (199277-23-1) → 2-phenyl-3-(thiophen-2-yl)-1H-indole (55654-00-7)

Guidance literature:

With disodium hydrogenphosphate; cyclohexa-1,4-diene; eosin Y; In acetonitrile; at 20 ℃; regiospecific reaction; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1039/c6cc10305g

upstream raw materials:

2-methoxythiophene

2-phenyl-indole

thiophene-2-sulfonyl chloride

1-azido-2-(phenylethynyl)benzene