2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde

Base Information

• Chemical Name: 2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde
• CAS No.: 1083433-29-7
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.328
• Mol file: 1083433-29-7.mol

Synonyms:2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde

Chemical Property of 2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde

There total 5 articles about 2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-2,4-dimethoxy-6-styrylbenzaldehyde → 2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde (1083433-29-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 18h;

Reference yield: 81.0%

1,3-dimethoxy-5-(2-phenylethyl)benzene (78916-50-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde (1083433-29-7)

Guidance literature:

With Vilsmeier reagent; trichlorophosphate; In N,N-dimethyl-formamide; at -4 - 20 ℃; for 21h;

DOI:10.1080/09168451.2019.1618699

Reference yield:

2-bromo-4,6-dimethoxybenzaldehyde (81574-69-8) → 2,4-dimethoxy-6-(2-phenylethyl)benzaldehyde (1083433-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; potassium phosphate / N,N-dimethyl acetamide / 120 °C / Inert atmosphere; Schlenk technique

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C

With potassium phosphate; palladium 10% on activated carbon; hydrogen; palladium diacetate; In N,N-dimethyl acetamide; ethyl acetate; 1: |Heck Reaction;

DOI:10.1021/acs.jnatprod.8b00315

upstream raw materials:

1,3-dimethoxy-5-(2-phenylethyl)benzene

N,N-dimethyl-formamide

1-bromo-3,5-dimethoxybenzene

2-bromo-4,6-dimethoxybenzaldehyde

Downstream raw materials:

2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)-6-(2-phenylethyl)benzoic acid