1-Bromo-3,5-dimethoxybenzene

Base Information

• Chemical Name: 1-Bromo-3,5-dimethoxybenzene
• CAS No.: 20469-65-2
• Molecular Formula: C8H9BrO2
• Molecular Weight: 217.062
• Hs Code.: 29093090
• Mol file: 20469-65-2.mol

Synonyms:3,5-Dimethoxy-1-bromobenzene;3,5-Dimethoxybromobenzene;3,5-Dimethoxyphenylbromide;5-Bromo-1,3-dimethoxybenzene;

Chemical Property of 1-Bromo-3,5-dimethoxybenzene

Chemical Property:

• Vapor Pressure: 0.0435mmHg at 25°C
• Melting Point: 62-66 °C(lit.)
• Refractive Index: 1.527
• Boiling Point: 246 °C at 760 mmHg
• Flash Point: 103.1 °C
• PSA: 18.46000
• Density: 1.412 g/cm³
• LogP: 2.46630
• Storage Temp.: Room temperature.
• Solubility.: Soluble in methanol.

Purity/Quality:

99.9% ^*data from raw suppliers

1-Bromo-3,5-dimethoxybenzene ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bromo-3,5-dimethoxybenzene may be used to synthesize the following:bis-[di-(3,5-dimethoxyphenyl)methylcyclopentadienyl]titanium(IV)dichloride,{η5 - C5H4-CH-[C6H4-(OCH3)2]2)2TiCl2 which can be used as an anti-cancer drug and is obtained via a multistep reaction process5-bromo-benzene-1,3-diol via demethylation with boron tribromide(BBr3)1-bromo-3,5-dimethoxy-2-nitrobenzene via nitration reaction 1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.

Technology Process of 1-Bromo-3,5-dimethoxybenzene

There total 13 articles about 1-Bromo-3,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,3-Dimethoxybenzene (151-10-0) → 1-bromo-3,5-dimethoxybenzene (20469-65-2)

Guidance literature:

With [bis(acetoxy)iodo]benzene; sodium bromide; for 0.5h;

Reference yield: 60.0%

3,5-dimethoxybenzoyl chloride (17213-57-9) → 1-bromo-3,5-dimethoxybenzene (20469-65-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); Bromotrichloromethane; 2-mercaptopyridine-1-oxide sodium salt; for 0.25h; Heating;

DOI:10.1002/(sici)1099-0690(199802)1998:2<359::aid-ejoc359>3.0.co;2-n

Reference yield: 55.8%

3.5-dimethoxyaniline (10272-07-8) → 1-bromo-3,5-dimethoxybenzene (20469-65-2)

Guidance literature:

3.5-dimethoxyaniline; With hydrogen bromide; sodium nitrite; at 0 ℃;

With hydrogen bromide; copper(I) bromide; for 0.5h; Heating;

DOI:10.1021/jm058175c

upstream raw materials:

3-bromo-5-methoxyphenol

dimethyl sulfate

3.5-dimethoxyaniline

1,3-Dimethoxybenzene

Downstream raw materials:

3,5-dimethoxyphenyl phenyl ether

5-bromoresorcinol

1,3-dimethoxy-5-(trimethylsilyl)benzene

1-[1-(3,5-Dimethoxy-phenyl)-cyclohexyl]-1,2,3,6-tetrahydro-pyridine

Refernces

• 1、 Iijima, Takashi,Makabe, Hidefumi. "Short-step synthesis of a resveratrol derivative from commercially available1,3-dimethoxybenzene and 4-vinylanisole". . p. 2547 - 2548. Retrieved 2009.
• 2、 Murphy, Jaclyn M.,Liao, Xuebin,Hartwig, John F.. "Meta halogenation of 1,3-disubstituted arenes via iridium-catalyzed arene borylation". . p. 15434 - 15435. Retrieved 2008/09/19.