(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester
CAS No.:1258451-17-0
Molecular Formula:C₁₉H₂₅NO₆S
Molecular Weight:395.477
Hs Code.:

Synonyms:(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester

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Chemical Property of (1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester

Chemical Property:

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Technology Process of (1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester

There total 6 articles about (1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258451-16-9
(1R,2R,4S)-2-(morpholine-4-carbonyl)-4-phenylsulfanyl-cyclopentanecarboxylic acid ethyl ester

: 1258451-17-0
(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 22 ℃;

Reference yield:

: (1R,2R,4S)-2-(morpholine-4-carbonyl)-4-phenylsulfanylcyclopentanecarboxylic acid ethyl ester

: 1258451-17-0
(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 22 ℃;
DOI:10.1021/jm401528k

Reference yield:

: (+/-)-trans-4-Oxo-1,2-cyclopentanedicarboxylic acid diethyl ester

: 1258451-17-0
(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4-morpholineethanesulfonic acid; magnesium(II) acetate tetrahydrate; sodium hydroxide; lipase from Candida antarctica B / aq. buffer / 42 h / 22 °C / pH 6.2 / Enzymatic reaction

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran / 22 °C

3.1: 4-morpholineethanesulfonic acid; D-glucose; magnesium(II) chloride hexahydrate; glucose dehydrogenase 102; ketoreductase NADP-131; nicotinamide adenine dinucleotide phosphate / aq. buffer / 21 h / 22 °C / pH 6.5

4.1: triethylamine / dichloromethane / 5 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

5.2: 50 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

With 4-morpholineethanesulfonic acid; lipase from Candida antarctica B; magnesium(II) chloride hexahydrate; D-glucose; glucose dehydrogenase 102; ketoreductase NADP-131; nicotinamide adenine dinucleotide phosphate; magnesium(II) acetate tetrahydrate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/jm401528k