(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid
CAS No.:1258451-18-1
Molecular Formula:C₁₇H₂₁NO₆S
Molecular Weight:367.423
Hs Code.:

Synonyms:(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid

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Chemical Property of (1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid

Chemical Property:

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Technology Process of (1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid

There total 7 articles about (1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258451-17-0
(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester

: 1258451-18-1
(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid

Guidance literature:: (1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid ethyl ester; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 22 ℃;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: (1R,2R,4S)-2-(morpholine-4-carbonyl)-4-phenylsulfanylcyclopentanecarboxylic acid ethyl ester

: 1258451-18-1
(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 22 °C

With water; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm401528k

Reference yield:

: 1258451-12-5
(1R,2R)-4-oxocyclopentane-1,2-dicarboxylic acid monoethyl ester

: 1258451-18-1
(1R,2R,4S)-4-benzenesulfonyl-2-(morpholine-4-carbonyl)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran / 22 °C

2.1: 4-morpholineethanesulfonic acid; D-glucose; magnesium(II) chloride hexahydrate; glucose dehydrogenase 102; ketoreductase NADP-131; nicotinamide adenine dinucleotide phosphate / aq. buffer / 21 h / 22 °C / pH 6.5

3.1: triethylamine / dichloromethane / 5 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

4.2: 50 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 22 °C

With 4-morpholineethanesulfonic acid; magnesium(II) chloride hexahydrate; D-glucose; glucose dehydrogenase 102; ketoreductase NADP-131; water; nicotinamide adenine dinucleotide phosphate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1021/jm401528k