N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine

Base Information

Chemical Name:N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine
CAS No.:1600518-04-4
Molecular Formula:C₂₃H₂₁BrN₂O₄S
Molecular Weight:501.401
Hs Code.:

Synonyms:N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine

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Chemical Property of N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine

Chemical Property:

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Technology Process of N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine

There total 4 articles about N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 19524-06-2
4-bromopyridine hydrochloride

: 541-41-3
chloroformic acid ethyl ester

: 312329-87-6
N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide

: 1600518-04-4
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 ℃; for 20h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo500365h

Reference yield:

: 68-34-8
phenyl toluenesulfonamide

: 1600518-04-4
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide

2: triphenylphosphine

3: n-butyllithium

4: copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 25 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In acetonitrile;
DOI:10.1021/jo500365h

Reference yield:

: 68984-88-3
N-Formyl-N-phenyl-4-methyl-benzenesulfonamide

: 1600518-04-4
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-4-bromopyridine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine

2: n-butyllithium

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 25 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In acetonitrile;
DOI:10.1021/jo500365h